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Q5 LONG ANSWER 10M ★ High-yield

Describe the normal electrocardiogram. Explain the leads, waves and intervals with their normal values, and give the uses of the ECG.

Physiology · 1st Professional — Pre-Clinical

Definition

Electrocardiogram (ECG) = the graphic record of the electrical activity of the heart as recorded from the body surface.

  • Recorded at a paper speed of 25 mm/s and a sensitivity of 1 mV = 10 mm
  • Therefore 1 small square = 0.04 s and 1 large square = 0.2 s

Leads

GroupLeadsType
Bipolar limb (Einthoven)I, II, IIIRecord potential difference between two limbs
Augmented unipolar limbAVR, aVL, aVFOne limb vs an indifferent electrode
Unipolar chest (precordial)V1–V6Chest wall vs Wilson central terminal
  • Lead I = left arm − right arm; Lead II = left leg − right arm; Lead III = left leg − left arm
  • Einthoven's law — Lead II = Lead I + Lead III
  • AVR is normally negative in all its deflections

Regional correlation

LeadsRegion of heartArtery
II, III, aVFInferiorRight coronary
I, aVL, V5, V6LateralLeft circumflex
V1–V4Anterior / septalLeft anterior descending

Waves and Intervals

Wave / intervalRepresentsNormal durationNormal amplitude
P waveAtrial depolarisation0.08–0.10 s< 2.5 mm
PR intervalAtrial depolarisation + AV nodal delay0.12–0.20 s—
QRS complexVentricular depolarisation0.08–0.10 s—
ST segmentPlateau — ventricles fully depolarised0.08 sIsoelectric
T waveVentricular repolarisation0.2 s—
QT intervalTotal ventricular electrical activity0.40 s—
  • Atrial repolarisation is not seen — it is buried within the QRS complex
  • T wave is upright although it is repolarisation, because repolarisation proceeds from epicardium to endocardium, the reverse of depolarisation

Determination of Heart Rate and Axis

  • Rate = 300 ÷ number of large squares between two R waves
  • Or 1500 ÷ number of small squares
  • Normal QRS axis = −30° to +90°
  • Left axis deviation — LVH, left anterior hemiblock; right axis deviation — RVH, pulmonary embolism

Einthoven’s Triangle and the Cardiac Vector

  • The three bipolar limb leads form an equilateral triangle with the heart at its centre
  • The heart is regarded as a dipole in a volume conductor
  • Cardiac vector — the resultant of all the instantaneous electrical forces in the heart, having magnitude and direction
  • A wave is upright when depolarisation moves toward the positive electrode, and inverted when it moves away
  • Mean electrical axis is calculated from leads I and aVF, or from the isoelectric lead

Uses of ECG

  • Diagnosis of arrhythmias and heart block
  • Diagnosis and localisation of myocardial infarction
  • Detection of chamber hypertrophy
  • Detection of electrolyte disturbances
  • Assessing drug effects and toxicity (digitalis, antiarrhythmics)
  • Determination of heart rate and electrical axis

Applied Aspects

ConditionECG change
Acute MIST elevation → T inversion → pathological Q waves
Myocardial ischaemiaST depression, T inversion
HyperkalaemiaTall tented T waves, flat P, wide QRS
HypokalaemiaFlat T, prominent U wave, ST depression
HypocalcaemiaProlonged QT
HypercalcaemiaShortened QT
Atrial fibrillationAbsent P waves, irregularly irregular RR
Complete heart blockP waves independent of QRS
  • The ECG records electrical, not mechanical activity — a normal ECG can occur in a heart that is not pumping (pulseless electrical activity)

All questions in Cardiovascular System

  1. Q1Describe the cardiac cycle. Explain the pressure and volume changes in the left ventricle during one cycle. Add a note on the jugular venous pulse. ★
  2. Q2Define cardiac output. Describe its determinants and the factors regulating it. Add a note on the methods of its measurement. ★
  3. Q3Describe the short-term and long-term mechanisms regulating arterial blood pressure. Add a note on the renin–angiotensin system. ★
  4. Q4Describe the conducting system of the heart. Explain the genesis of the pacemaker potential and the properties of cardiac muscle. ★
  5. Q5Describe the normal electrocardiogram. Explain the leads, waves and intervals with their normal values, and give the uses of the ECG. ★
  6. SN1Enumerate the heart sounds. Give their causes, characteristics and areas of auscultation. ★
  7. SN2State Starling’s law of the heart. Explain its basis and significance. ★
  8. SN3Describe the baroreceptor reflex and give its significance. ★
  9. SN4Describe the coronary circulation and the factors regulating coronary blood flow. ★
  10. SN5Describe the triple response of Lewis. Add a note on the axon reflex.
  11. SN6Describe the fetal circulation and the changes that occur at birth. ★
  12. SN7Define shock. Classify it and describe the compensatory mechanisms. ★

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