Q4
LONG ANSWER
10M
★ High-yield
Describe the duties of a doctor in a case of poisoning and the collection and preservation of viscera.
Duties of the Doctor
| Duty | Detail |
|---|---|
| Treat first | Resuscitation and treatment precede every legal formality. Refusal or delay pending police clearance is unlawful (Parmanand Katara) and has killed people |
| Inform the police | Every case of suspected poisoning is a medicolegal case and must be intimated to the police in writing, with the time recorded. Failure may amount to an offence under BNS 239 (formerly IPC 201), causing disappearance of evidence |
| Preserve and hand over evidence | Vomit, the first gastric aspirate, urine, blood, the container, tablets, plant material, the syringe and the clothing — each labelled, sealed and handed over against signature |
| Record meticulously | The time of arrival and of every observation; the history as alleged and attributed; the clinical findings; what was given and when; and the identity of the person accompanying |
| Record a dying declaration | Where the patient is deteriorating — with certification of mental fitness before and after, in their own words, without leading, and excluding relatives who may be the accused |
| Do not destroy or discard anything | Gastric washings are routinely poured away and the container thrown out; both are evidence |
| In a case of a medical practitioner poisoning | The doctor must not shield a colleague or an institution; the obligation to report is the same |
- A doctor in private practice has the same obligations as one in government service, and there is no discretion to treat a poisoning case quietly to avoid police involvement — a course frequently urged by families and by institutions
- The treating doctor is usually the only person who will ever see the early clinical picture, the container and the first aspirate; whatever they fail to record or preserve is lost permanently
Preservation of Viscera
| Specimen | Quantity and notes |
|---|---|
| Stomach and its contents | The whole stomach, opened along the greater curvature, with all its contents; ligated at both ends before removal |
| Upper part of the small intestine with contents | About the first 30 cm of duodenum and jejunum, ligated — important where death was delayed and the stomach has emptied |
| Liver | About 500 g — the organ of metabolism and storage, and the single most useful solid organ |
| Kidney | One half of each kidney |
| Blood | About 100 mL, preferably peripheral (femoral) rather than cardiac, to avoid postmortem redistribution |
| Urine | About 100 mL, the whole available |
| Special specimens | Brain — for volatile poisons, alcohol, hydrocarbons and organophosphates; lung — for inhaled poisons; bone, hair and nails — for arsenic, thallium and heavy metals in chronic poisoning; long bone — for lead and radium; skin and underlying tissue around an injection site; the gravid uterus; vitreous humour — which resists putrefaction and is invaluable in a decomposed body |
| Preservative | Use and exceptions |
|---|---|
| Saturated saline (common salt solution) | The routine preservative for viscera, in a quantity covering them by about 2 to 3 cm |
| Rectified spirit | An alternative — but never where alcohol, paraldehyde, chloroform, ether or acetic acid is suspected, since it makes the result uninterpretable |
| Sodium fluoride with potassium oxalate | For blood alcohol — the fluoride prevents both bacterial fermentation (which generates alcohol after death) and glycolysis. Also used for blood sugar |
| NO preservative AT all | For carbon monoxide, cyanide and phosphorus — the specimen is sent in a clean, airtight container, filled to the brim and refrigerated |
| Never formalin | Formalin interferes with the detection of several poisons and must not be used for material intended for chemical analysis; it is for histology only |
CLINICAL PEARL
Rectified spirit in an alcohol case, and formalin in any case, destroy the analysis. Preserving viscera in spirit when the question is whether the driver had been drinking makes the result meaningless; and formalin interferes with the detection of several poisons outright. Saturated saline is the default, fluoride is for alcohol, and carbon monoxide, cyanide and phosphorus get no preservative at all — four rules that cover almost every case.
Packing, Sealing and Dispatch
- Containers — clean, dry, wide-mouthed glass jars with a glass or plastic stopper; filled to about two-thirds; and a separate jar for each specimen, since mixing renders the analysis uninterpretable
- Labelling — the name of the deceased, the autopsy and inquest number, the police station and case number, the date, the contents, the preservative used, and the signature of the doctor
- Sealing — each jar sealed with the doctor’s own seal, and a sample OF the preservative sent in a separate sealed jar, together with a specimen impression OF the seal on a separate paper — so that the chemical examiner can confirm that the preservative was not itself contaminated and that the jars were not opened in transit
- The chain OF custody — handed to the police officer against signature, with a forwarding letter listing the specimens, the history and the suspected poison, and a copy retained. A break in the chain destroys the value of the analysis however accurate the result
- Despatch — to the Forensic Science Laboratory or the Chemical Examiner, as soon as possible, refrigerated where required. The doctor should state what poison is suspected, since the laboratory cannot screen for everything and a general request produces a general answer
Applied Aspects
- State the suspected poison on the requisition; a laboratory asked to "examine for poison" will run a routine screen that misses many agents entirely, and the history is what directs the analysis
- Send a sample of the preservative and an impression of the seal; without them the defence can suggest contamination or tampering and the analysis is weakened
- Use one jar per specimen and fill only to two-thirds; mixed viscera cannot be interpreted and a full jar bursts on transport
- Take femoral rather than cardiac blood where possible; postmortem redistribution from the gut and lungs into the heart chambers falsely raises the concentration of many drugs
- Preserve viscera even where the cause seems obvious; the body is released within hours and the material cannot be recovered, and a negative screen excludes a defence that would otherwise be raised
- Never let anyone discard the gastric washings; they are the highest-concentration specimen available and are lost more often than any other
- Vitreous humour resists putrefaction and is invaluable in a decomposed body where blood is useless
- Take hair, nails and bone in suspected chronic poisoning; they give a chronological record that soft tissues cannot
- Ligate the stomach at both ends before removal, and send it whole with all its contents rather than a sample
- Take the brain for volatile poisons — alcohol, hydrocarbons, organophosphates — and the lung for anything inhaled
- Record the time of every observation; in a poisoning case the sequence and timing are frequently the whole issue
- Do not shield a colleague or an institution; the duty to report a poisoning case is the same wherever it arose
- Never use formalin for material going to chemical analysis; it interferes with the detection of several poisons and is for histology only
- Never use rectified spirit where alcohol is the question; it makes the result meaningless, and paraldehyde and chloroform are affected too
- Carbon monoxide, cyanide and phosphorus get no preservative and go in a full airtight container, refrigerated
- Send a sample of the preservative itself, so the examiner can exclude contamination from that source
- Treat first and inform the police afterwards; refusal pending police clearance is unlawful and has killed people
- A private practitioner has identical obligations; there is no discretion to handle a poisoning case quietly
- State the suspected poison on the requisition; a general request produces a routine screen that misses many agents entirely
- One jar per specimen, filled to two-thirds; mixed viscera cannot be interpreted and a full jar bursts in transit
- Send an impression of your seal separately, so tampering in transit can be excluded by the examiner
- A break in the chain of custody destroys the analysis however accurate the laboratory result may be
All questions in General Toxicology
- Q1Define poison. Describe the classification of poisons, the factors modifying their action and the laws relating to them. ★
- Q2Describe the diagnosis of poisoning in the living and in the dead. ★
- Q3Describe the general management of a case of acute poisoning including decontamination and antidotes. ★
- Q4Describe the duties of a doctor in a case of poisoning and the collection and preservation of viscera. ★
- Q5Describe the poisoning by arsenic, lead and mercury. ★
- SN1Describe the chelating agents with their uses and precautions. ★
- SN2Describe copper sulphate poisoning. ★
- SN3Describe iron poisoning with its stages and management. ★
- SN4Describe aluminium phosphide poisoning and the other rodenticides. ★
- SN5Describe food poisoning with its types and investigation. ★
- SN6Describe carbon monoxide poisoning. ★
- SN7Describe cyanide poisoning with its mechanism and treatment.